The role of the central histaminergic system in emergence from propofol anesthesia in rats model

Background: The mechanisms of emergence from general anesthesia remain to be elucidated. Recent studies indicate that the central histaminergic system plays a critical role in maintaining wakefulness. In addition, neural pathways regulate wake-sleep cycle are involved anesthesia. this study, we determined propofol using microinjections and single-unit recordings rats.